Latest publications

Sample size considerations for n-of-1 trials.

  • Competence Center for Methodology and Statistics
February 01, 2019
2019 Feb. Stat Methods Med Res.28(2):372-383. Epub 2017 Sep 7.
By:
  • Senn S.

Le LIH coordonne la phase clinique d’un vaccin thérapeutique contre le VIH.

  • Clinical and Epidemiological Investigation Center
February 01, 2019
2019 Feb. Semper Luxembourg.(110):14-16.
By:
  • de Bremaeker N
  • Gantenbein M.

Public health burden of pre-diabetes and diabetes in Luxembourg: finding from the 2013-2015 European Health Examination Survey.

  • Competence Center for Methodology and Statistics
January 21, 2019
2019 Jan. BMJ Open.9(1):e022206.
By:
  • Bocquet V
  • Ruiz-Castell M
  • de Beaufort C
  • Barre J
  • de Rekeneire N
  • Michel G
  • Donahue RP
  • Kuemmerle A
  • Stranges S.

"To survey or to register" is that the question for estimating population incidence of injuries?

  • Competence Center for Methodology and Statistics
December 17, 2018
2018 Dec. Arch Public Health.76(1):76.
By:
  • Bejko D
  • Ruiz-Castell M
  • Schritz A
  • Laursen B
  • Kisser R
  • Rogmans W
  • Lyons RA
  • Valkenberg H
  • Turner S
  • Bauer R
  • Ellsaesser G
  • de Rekeneire N.

Effect of predicted low suspend pump treatment on improving glycaemic control and quality of sleep in children with type 1 diabetes and their caregivers: the QUEST randomized crossover study.

  • Competence Center for Methodology and Statistics
December 04, 2018
2018 Dec. Trials.19(1):665.
By:
  • Schierloh U
  • Aguayo GA
  • Fichelle M
  • De Melo Dias C
  • Celebic A
  • Vaillant M
  • Barnard K
  • Cohen O
  • de Beaufort C.

Health economic impact of liquid biopsies in cancer management.

  • Competence Center for Methodology and Statistics
December 01, 2018
2018 Dec. Expert Rev Pharmacoecon Outcomes Res.18(6):593-599. Epub 2018 Aug 7.
By:
  • IJzerman M
  • Berghuis AMS
  • de Bono JS
  • Terstappen L.

The future of precision medicine: Potential impacts for health technology assessment.

  • Competence Center for Methodology and Statistics
December 01, 2018
2018 Dec. Pharmacoeconomics.36(12):1439-1451.
By:
  • Love-Koh J
  • Peel A
  • Rejon-Parrilla JC
  • Ennis K
  • Lovett R
  • Manca A
  • Chalkidou A
  • Wood H
  • Taylor M.

Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis.

  • Competence Center for Methodology and Statistics
December 01, 2018
2018 Dec. Environ Int.121(Pt 2):1341-1354. Epub 2018 Nov 9.
By:
  • Palazzi P
  • Mezzache S
  • Bourokba N
  • Hardy EM
  • Schritz A
  • Bastien P
  • Emond C
  • Li J
  • Soeur J
  • Appenzeller BMR.

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

  • Competence Center for Methodology and Statistics
November 20, 2018
2018 Nov. Trials.19(1):642.
By:
  • Collignon O
  • Koenig F
  • Koch A
  • Hemmings RJ
  • Petavy F
  • Saint-Raymond A
  • Papaluca-Amati M
  • Posch M.

Statistical pitfalls of personalized medicine.

  • Competence Center for Methodology and Statistics
November 01, 2018
2018 Nov. Nature.563(7733):619-621.
By:
  • Senn S.

The Luxembourg Parkinson's study: A comprehensive approach for stratification and early diagnosis.

  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
October 29, 2018
2018 Oct. Front Aging Neurosci.10:326.
By:
  • Hipp G
  • Vaillant M
  • Diederich NJ
  • Roomp K
  • Satagopam VP
  • Banda P
  • Sandt E
  • Mommaerts K
  • Schmitz SK
  • Longhino L
  • Schweicher A
  • Hanff AM
  • Nicolai B
  • Kolber P
  • Reiter D
  • Pavelka L
  • Binck S
  • Pauly C
  • Geffers L
  • Betsou F
  • Gantenbein M
  • Klucken J
  • Gasser T
  • Hu MT
  • Balling R
  • Kruger R.

Study design and characteristics of the Luxembourg European Health Examination Survey (EHES-LUX).

  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
October 11, 2018
2018 Oct. BMC Public Health.18(1):1169.
By:
  • Bocquet V
  • Barre J
  • Couffignal S
  • d'Incau M
  • Delagardelle C
  • Michel G
  • Schlesser M
  • Stranges S
  • Kuemmerle A
  • Ruiz-Castell M.

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial.

  • Competence Center for Methodology and Statistics
October 06, 2018
2018 Oct. Lancet.392(10154):1207-1216. Epub 2018 Jan 18.
By:
  • Opoku NO
  • Bakajika DK
  • Kanza EM
  • Howard H
  • Mambandu GL
  • Nyathirombo A
  • Nigo MM
  • Kasonia K
  • Masembe SL
  • Mumbere M
  • Kataliko K
  • Larbelee JP
  • Kpawor M
  • Bolay KM
  • Bolay F
  • Asare S
  • Attah SK
  • Olipoh G
  • Vaillant M
  • Halleux CM
  • Kuesel AC
  • Sampson A.

Comparison of the modified unbounded penalty and the LASSO to select predictive genes of response to chemotherapy in breast cancer.

  • Competence Center for Methodology and Statistics
October 01, 2018
2018 Oct. PLoS One.13(10):e0204897.
By:
  • Collignon O
  • Han J
  • An H
  • Oh S
  • Lee Y.

Le LIH coordonne la phase clinique d’études pédiatriques européennes.

  • Clinical and Epidemiological Investigation Center
October 01, 2018
2018 Oct. Semper Luxembourg.(106):38-40.
By:
  • De Bremaeker N.

Regulatory assessment of drug dissolution profiles comparability via maximum deviation.

  • Competence Center for Methodology and Statistics
September 10, 2018
2018 Sep. Stat Med.37(20):2968-2981. Epub 2018 Jun 3.
By:
  • Moellenhoff K
  • Dette H
  • Kotzagiorgis E
  • Volgushev S
  • Collignon O.

Multi-arm, multi-drug trials from a reimbursement perspective. In Platform Trial Designs in Drug Development: Umbrella Trials and Basket Trials. (Book Chapter)

  • Competence Center for Methodology and Statistics
September 01, 2018
2018 Sep. Zoran Antonijevic Z and Beckman RA, eds. New York: Chapman and Hall/CRC 2018. p.119-124. (Chapman and Hall/CRC Biostatistics Series). ISBN 978-1138052451.
By:
  • Schiel A
  • Collignon O.

Statistical Analysis of Series of N-of-1 Trials

  • Competence Center for Methodology and Statistics
September 01, 2018
2018 Sep. 2018. 205 p.
By:
  • Araujo A.

Application of constrained optimization methods in health services research: Report 2 of the ISPOR optimization methods emerging good practices task force.

  • Competence Center for Methodology and Statistics
September 01, 2018
2018 Sep. Value Health.21(9):1019-1028.
By:
  • Crown W
  • Buyukkaramikli N
  • Sir MY
  • Thokala P
  • Morton A
  • Marshall DA
  • Tosh JC
  • Ijzerman MJ
  • Padula WV
  • Pasupathy KS.

Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.

  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
August 06, 2018
2018 Aug. Br J Cancer.119(5):580-590. Epub 2018 Aug 6.
By:
  • El-Khoury V
  • Beland M
  • Schritz A
  • Kim SY
  • Nazarov PV
  • Gaboury L
  • Sertamo K
  • Bernardin F
  • Batutu R
  • Antunes L
  • Bennett CW
  • Fays F
  • Berchem G
  • Kim YJ.