WEBINAR: Metabolic rewiring driving metastasis formation - Prof Sarah-Maria FENDT
22/04/2021 14:00 to 22/04/2021 15:30 (Europe/Luxembourg)
Speaker
Prof Sarah Maria FENDT
Group Leader Laboratory of Cellular Metabolism and Metabolic Regulation
VIB-KU Leuven Center for Cancer Biology
ABSTRACT
Metabolic rewiring is a hallmark of cancer cells However, how nutrients drive the ability of cancer cells to rewire their metabolism is poorly defined We are investigating the in vivo nutrient metabolism during metastasis formation to mechanistically understand how nutrients from the microenvironment enable cancers to progress from a local to a systemic disease Using 13 C tracer infusions in mouse models we find that nutrient availability shapes the metabolism and phenotype of cells and subsequently promotes the progression of cancer Consequently, interfering with nutrient metabolism emerges as a promising therapeutic strategy against cancer Taken together, our research highlights that nutrient metabolism is an important driver of cancer progression.