Lecture Series Translational Bioinformatics & Systems Biomedicine - "Quantifying intratumoral heterogeneity at single cell level" - Prof Andrei Zinovyev
26/06/2018 16:00 to 26/06/2018 18:30 (Europe/Luxembourg)
Speaker
Prof Andrei Zinovyev is Scientific coordinator of Computational Systems Biology of Cancer group, Bioinformatics department of Institut Curie, Paris, France.
Abstract
Single cell measurements change the modern biology due to bringing the ‘Big Data’-related approaches and challenges to the studies of normal physiology and diseases such as cancer. A number of novel computational methods and paradigms have emerged to deal with complexity of single cell genomic and epigenomic data. In this talk, I will present several methods for dealing with large and complex single-cell RNASeq datasets, including Independent Component Analysis for identification of hidden factors shaping cell populations and ElPiGraph method for quantifying branching or circular pseudo-time. I will present our recent single cell study of heterogeneity of tumors of Ewing sarcoma, starting from characterizing the cell cycle-independent transcriptional program of EWS/FLI-1 oncogene in inducible cell line and finishing by the analysis of patient-derived xenografts profiled with 10x Genomics platform. Our study shows that the tumors of Ewing sarcoma are characterized by intratumoral heterogeneity strongly associated with activity of the EWS/FLI-1 oncogene, with existence of tumor cell subpopulations characterized by specific and unexpected biological properties.
schedule
16.00 - 17.00: LECTURE
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Blackbox room
17.00 - 18.30: 'meet THE SPEAKER'
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Room N°0.202
Registration required for the 'Meet the Speaker' - send us an email
programme 2017-2018
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.