Lecture Series Translational Bioinformatics & Systems Biomedicine - "Mechanistic models of pathways detect new therapeutic targets and predict the effect of interventions" - Prof Joaquin Dopazo
04/09/2018 16:00 to 04/09/2018 18:30 (Europe/Luxembourg)
Speaker
Prof Joaquin Dopazo is Head of the Clinical Bioinformatics Area, Fundacion
Progreso y Salud. CDCA, Hospital Virgen del Rocis, Sevilla, Spain.
Abstract
In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of gene mutations or gene expression perturbations and the correct and detailed understanding of their contribution to the molecular mechanisms that ultimately account for the phenotype studied. Alterations in cell signaling and metabolism are behind the initiation and progression of many diseases, including cancer. Signaling and metabolic pathways compile a wealth of knowledge on relevant biological processes in the format of maps that describe the complex network of different interaction types among proteins and molecules. Such maps can be used to derive mechanistic models that link gene expression perturbations and/or mutations to changes in the metabolic and signaling activity that provide relevant clues on molecular mechanisms of disease and drug modes of action (MoA). Moreover, mechanistic models can be used to detect potential therapeutic targets that cause the desired effect on specific outcomes of disease or drug action mechanisms as well as to predict the effect of interventions on specific genes.
schedule
16.00 - 17.00: LECTURE
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Blackbox room
17.00 - 18.30: 'meet THE SPEAKER'
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Room N°0.206
Registration required for the 'Meet the Speaker' - send us an email
programme 2017-2018
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.