Lecture Series Translational Bioinformatics & Systems Biomedicine - "Integrative approaches and workflows to identify disease specific biomarkers and therapeutic candidates" - Prof Shailendra Gupta

03/05/2018 16:00 to 03/05/2018 18:30 (Europe/Luxembourg)


Prof Shailendra GUPTA is Scientist, Department of Systems Biology & Bioinformatics, University of Rostock, Germany, Senior Scientist (Bioinformatics), Systems Toxicology Group, CSIR – Indian Institute of Toxicology Research, Lucknow, India.



Unravelling mechanisms underlying diseases for the prediction of disease markers has motivated the development of various systems biology approaches. Key challenges for the development of mathematical models to mimic the real biological scenario is (i) the size of interacting biological components, (ii) the nonlinear nature of spatio-temporal interactions and (iii) feedback loops in the structure of interaction networks. Exploring large scale networks is an art where several analytic tools are integrated in a computational workflow to identify disease specific small regulatory modules. These small modules are subjected to a more detailed analysis using mathematical modeling for the prediction of disease signatures, i.e. set of network derived diagnostic/prognostic biomarkers. I shall discuss an integrative workflow to study large-scale biochemical disease networks by combining techniques from bioinformatics and systems biology in the context of tumor metastasis. In particular, I will highlight methodology using an algorithm employing multiobjective optimization concepts to rank and select key regulatory motifs mainly responsible for network dynamics and helps in generating process specific hypotheses on which a systems biology model can be constructed for the excellent guesswork of disease markers and therapeutic candidates.



16.00 - 17.00: LECTURE

University of Luxembourg

Maison du Savoir

2, avenue de l'Université

L-4365 Esch/Alzette

Room 4.530

17.00 - 18.30: 'meet THE SPEAKER'

University of Luxembourg

Maison du Savoir

2, avenue de l'Université

L-4365 Esch/Alzette

Room 4.200

Registration required for the 'Meet the Speaker' - send us an email

programme 2017-2018


The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Translational Bioinformatics and Systems Biomedicine.  Please find here  the full programme for 2017-2018.

This lecture will be followed by a workshop especially dedicated to early-stage researchers.

Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.


From 03/05/2018 16:00
To 03/05/2018 18:30


Luxembourg Institute of Health
+352 26 970
+352 26 970 719