Lecture Series Translational Bioinformatics & Systems Biomedicine - "Hunt for the tipping points of diseases by dynamic network biomarkers" - Prof Luonan Chen
19/06/2017 16:00 to 19/06/2017 18:30 (Europe/Luxembourg)
Speaker
Prof Luonan CHEN is Director, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Abstract
Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition from one state to another at a tipping point. Here, we develop a model-free method to detect early-warning signals of such critical transitions, even with only a small number of samples. Specifically, we theoretically derive an index based on a dynamical network biomarker (DNB) that serves as a general early-warning signal indicating an imminent bifurcation or sudden deterioration before the critical transition occurs. Based on theoretical analyses, we show that predicting a sudden transition from small samples is achievable provided that there are a large number of measurements for each sample, e.g., high-throughput data. We employ RNA-seq and microarray data of three diseases (cancers) to demonstrate the effectiveness of our method. The relevance of DNBs with the diseases was also validated by related experimental data and functional analysis.
For more information, please visit our website: www.sibcb.ac.cn/ePI.asp?id=163
schedule
16.00 - 17.00: LECTURE
University of Luxembourg
Campus Belval - House of Biomedicine II - Room 15 (ground floor)
17.00 - 18.30: 'meet THE SPEAKER'
University of Luxembourg
Campus Belval - House of Biomedicine II - Room 15 (ground floor)
Registration required for the 'Meet the Speaker' - send us an email
programme 2017-2018
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Translational Bioinformatics and Systems Biomedicine. Please find here the full programme for 2017-2018.
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.