Lecture Series Translational Bioinformatics & Systems Biomedicine - "Biological interrogation of integrated resources of high-throughput chemical and phenotypic data of perturbations" - Prof Mónica CAMPILLOS
11/09/2017 16:00 to 11/09/2017 18:30 (Europe/Luxembourg)
Speaker
Prof Mónica CAMPILLOS, Group leader at Helmholtz Zentrum München (HMGU), German Research Center for Environmental Health, Munich, Germany (Systems Pharmacology)
Abstract
In this talk, I will give an overview of the research activities of my research group at the Helmholtz Zentrum München. We are interested in understanding the phenotypic response of chemical and genetic perturbations in mammalian organism. To that aim, we have developed integrated resources and tools of high-throughput chemical screens as well as organismal phenotypes from genetic and chemical perturbations. These include the target prediction method HitPick and the Organ System Heterogeneity database. The interrogation of these resources using systems biology approaches has revealed novel insights into the drug/target/phenotype relation, extending the current knowledge on drug action. For example, we have predicted novel drug contraindications exploiting the similarity of drug side effects and disease symptoms. The application of novel drug target de-convolution methods to chemical high-throughput screens have enabled to uncover new connections between drugs targets and phenotypes. Novel findings have been experimentally validated in collaboration with lab research groups.
schedule
16.00 - 17.00: LECTURE
Maison des Sciences
Humaines
“Blackbox room“
11, porte des Sciences
L-4366 Esch-sur-Alzette
17.00 - 18.30: 'meet THE SPEAKER'
Maison des Sciences
Humaines
Room N°0015050
Registration required for the 'Meet the Speaker' - send us an email
programme 2017-2018
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Translational Bioinformatics and Systems Biomedicine. Please find here the full programme for 2017-2018.
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.