Lecture series Translational Bioinformatics and Systems Biomedicine "QUANTITATIVE SYSTEMS PHARMACOLOGY OF INTERFERON ALPHA ADMINISTRATION: A MULTI-SCALE APPROACH" - Prof Ursula Kummer
03/12/2018 16:00 to 03/12/2018 18:30 (Europe/Luxembourg)
Speaker
Prof Ursula Kummer is Full Professor, Heidelberg University, Germany.
Abstract
The therapeutic effect of a drug is governed by pharmacokinetics (PK) which determines the exposure at the target site as well as the downstream pharmacodynamic (PD) response within the cellular network. Computational modelling of both individual scales has been successfully established in the past. However, coupling and integration of both scales remains challenging but would provide a unique possibility of mechanistic and holistic analyses of detailed dose effects under different conditions and/or in a personalised manner. In this talk, methodology to combine whole-body PBPK models with mechanistic intracellular models is presented using the example of signal transduction in the liver for IFN-α in human. In this case, the multi- scale PBPK/PD model indicates receptor saturation at low injected doses and gives mechanistic insights into the PD response which is several times lower as compared to the response in isolated hepatocytes and with normally chosen experimental in vitro doses for IFN-α.
schedule
16.00 - 17.00: LECTURE
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Blackbox room
17.00 - 18.30: 'meet THE SPEAKER'
University of Luxembourg
Maison des Sciences Humaines
11, Porte des Sciences
L-4366 Esch/Alzette
Room N°0015010
Registration required for the 'Meet the Speaker' - send us an email
programme 2018-2019
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.