Lecture series Translational Bioinformatics and Systems Biomedicine "QUANTITATIVE SYSTEMS PHARMACOLOGY OF INTERFERON ALPHA ADMINISTRATION: A MULTI-SCALE APPROACH" - Prof Ursula Kummer

03/12/2018 16:00 to 03/12/2018 18:30 (Europe/Luxembourg)

Speaker

Prof Ursula Kummer is Full Professor, Heidelberg University, Germany.

 

Abstract

The therapeutic effect of a drug is governed by pharmacokinetics (PK) which determines the exposure at the target site as well as the downstream pharmacodynamic (PD) response within the cellular network. Computational modelling of both individual scales has been successfully established in the past. However, coupling and integration of both scales remains challenging but would provide a unique possibility of mechanistic and holistic analyses of detailed dose effects under different conditions and/or in a personalised manner. In this talk, methodology to combine whole-body PBPK models with mechanistic intracellular models is presented using the example of signal transduction in the liver for IFN-α in human. In this case, the multi- scale PBPK/PD model indicates receptor saturation at low injected doses and gives mechanistic insights into the PD response which is several times lower as compared to the response in isolated hepatocytes and with normally chosen experimental in vitro doses for IFN-α.

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schedule

16.00 - 17.00: LECTURE

University of Luxembourg

Maison des Sciences Humaines

11, Porte des Sciences 

L-4366 Esch/Alzette

Blackbox room

17.00 - 18.30: 'meet THE SPEAKER'

University of Luxembourg

Maison des Sciences Humaines

11, Porte des Sciences

L-4366 Esch/Alzette

Room N°0015010


Registration required for the 'Meet the Speaker' - send us an email

programme 2018-2019

About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE

The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Translational Bioinformatics and Systems Biomedicine.  Please find here  the full programme for 2018-2019.

This lecture will be followed by a workshop especially dedicated to early-stage researchers.

Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.

When

From 03/12/2018 16:00
To 03/12/2018 18:30

Contact

Luxembourg Institute of Health
+352 26 970
+352 26 970 719
odoo@lih.lu