Lecture series Translational Bioinformatics and Systems Biomedicine "IDENTIFYING DRUGGABLE GENETIC DEPENDENCIES FOR PERSONALIZED CANCER THERAPY" - Dr Fatima Al-Shahrour
21/03/2019 16:30 to 21/03/2019 18:15 (Europe/Luxembourg)
--University of Luxembourg - University of Luxembourg, Sciences Humaines Maison des--
Speaker
Dr Fatima Al-Shahrour is Head of Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Abstract
The paradigm of personalized medicine is the identification of the appropriate drug for the right patient, using molecular profiles. In Oncology, it is well established that the anticancer drugs are effective in only a small subset of patients. Moreover, many of the new targeted therapies inhibit specific proteins, and they are only effective in tumors that are genetically altered. Consequently, the success of personalized treatment depends on each individual molecular profile, which a priori can be considered as very heterogeneous. Here, we present new computational approaches based on the analysis and integration of genomic data (mutations, copy number variations or gene expression levels), with functional data (protein essentiality) and pharmacological data. These methods aim to identify those vulnerable molecular alterations that drive tumor progression and could be druggable based on the patient’s molecular profile, and propose an individualized therapeutic strategy to guide clinical decision making for cancer patients.
schedule
16.30 - 17.30: LECTURE
University of Luxembourg
Maison des Sciences Humaines
Blackbox room
17.30 - 18.15: 'meet THE SPEAKER'
University of Luxembourg
Maison des Sciences Humaines
Room N°0.205
Registration required for the 'Meet the Speaker' - send us an email
programme 2019
About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE
The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.