Lecture Series "Infection & Immunity" - Prof Kiyoshi Takeda - "Mechanisms for regulation of intestinal Homeostasis"

22/02/2018 11:00 to 22/02/2018 14:00 (Europe/Luxembourg)

Esch/Alzette, Luxembourg


Prof Kiyoshi Takeda is Professor, Department of Microbiology and Immunology, Graduate School of Medicin and of Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Japan.


Intestine is a unique tissue where a variety of environmental factors including commensal microbiota and dietary components exist. In a healthy condition, activity of intestinal immunity is finely regulated to prevent inflammatory responses to these environmental factors. Dysregulated interaction of intestinal environmental factors and intestinal immunity causes development of inflammatory bowel disease (IBD) represented by Crohn’s disease and ulcerative colitis.

We are analyzing the mechanisms by which gut homeostasis is regulated by focusing on intestinal innate immunity. There are several unique subsets of innate immune cells in the murine intestinal lamina propria, which regulate immune responses positively and negatively. We then identified human counterparts of these cell subsets in the human colon, and activity of these subsets were altered in IBD patients. Thus, intestinal innate immune cells are critically involved in the pathogenesis of intestinal inflammation.

We also analyze barrier function of colonic epithelial cells that are responsible for segregation of intestinal environmental factors and immunity, contributing to prevention of intestinal inflammation. Indeed, the presence of bacteria on the epithelial surface of the large intestine was reported in several mouse models of intestinal inflammation. We identified a molecule that is produced from the epithelial cells and is responsible for the segregation of microbiota and the host immunity. This molecule is thus essential for the maintenance of gut homeostasis.



11:00 - 12:00 : LECTURE

Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle

12:30 - 14:00 : 'meet & eat'

House of BioHealth
Room Françoise Barré-Sinoussi

Registration required for the 'Meet & Eat' - send us an email.

About the Lecture & Workshop series - Infection & Immunity

The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2018, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2018.

Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.


32 rue Henri Koch
    Esch/Alzette 4354


From 22/02/2018 11:00
To 22/02/2018 14:00


Luxembourg Institute of Health
+352 26 970
+352 26 970 719