Lecture Series Infection & Immunity - Next-generation of multi-omics research:going to the single cell - Prof Karsten Hiller: "Suppressing the fire: immunomodulatory metabolites in macrophages"
08/12/2021 11:00 to 08/12/2021 12:00 (Europe/Luxembourg)
ESCH-SUR-ALZETTE,
Luxembourg
Speaker
Prof Karsten Hiller is W3 Professor of Biochemistry and Bioinformatics, TU Braunschweig, Director of Department for Bioinformatics and Biochemistry,
TU Braunschweig, Deputy Director of Braunscheig Integrated Centre
of Systems Biology (BRICS).
Abstract
With the discovery of itaconate and its biochemical synthesis pathway in mammalina macrophages, a new research field in immunometablism has been established. Besides its antimicrobial role, itaconate inhibits mitochondrial SDH/Complex II and is thus involved in the modulation of macrophage metabolism. Moreover, several groups demonstrated an anti-inflammatory activity of itaconate and demonstrated that itaconate suppresssed Il-6 and Il-12 expression and secretion. Potential mechanisms for this immunomodulatory function were proposed for the itaconate esters dimethylitaconate and 4-octylitaconate either via activation of Atf3 or inhibition of KEAP1, respectively. During my presentation, I will present new results from our lab that indicate that itaconate is not the only immunomodulatory metabolite synthesized by mammalian macrophages. In addition, I will present new data that demonstrates that the anti-inflammatory activity of underivatized itaconate is independent of Nrf2 and Atf3.
schedule
11.00-12.00: LECTURE
University of Luxembourg
Maison du Savoir, Auditorium 3.500
2, avenue de l'Université
L-4365 Esch-sur-Alzette
About the Lecture & Workshop series - Infection & Immunity - Next-generation of multi-omics research: going to the single cell
The LIH lecture and workshops series in Infection & Immunity (Next-generation of multi-omics research:going to the single cell), supported by the FNR and jointly organized with the University of Luxembourg-LCSB, are gathering internationally recognised speakers to address these research topics during 2021-2022.
Attendance to the lecture is free of charge.
Please kindly note that the event will be held under covid check measures with a maximum capacity of 240 persons for the lecture. Please kindly register with Florence.henry@lih.lu indicating if you wish to attend the lecture (the registrations will be confirmed on first come, first served basis).