Lecture series Infection & Immunity: "CONSERVED FEVER PATHWAYS ACROSS VERTEBRATES: A HERPESVIRUS DELAYS FISH BEHAVIORAL FEVER THROUGH EXPRESSION OF A DECOY TNFα RECEPTOR" - Prof Alain Vanderplasschen
23/05/2019 11:00 to 23/05/2019 14:00 (Europe/Luxembourg)
Esch/Alzette,
Luxembourg
Speaker
Prof Alain Vanderplasschen is Head of Laboratory of Immunology-Vaccinology, Faculty of Veterinary Medicine, University of Liège, Belgium.
ABSTRACT
When infected by pathogens, endotherms and ectotherms can both increase their body temperature to limit the infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever”. We studied the expression of behavioral fever by common carp infected by cyprinid herpesvirus 3. We showed that carp maintained at 24°C all died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C-32°C gradient all survived as a consequence of their transient migration to the warmest compartment. As the expression of behavioral fever occurred only at an advanced stage of the disease, we hypothesized that the virus might delay this phenomenon in order to promote its replication. The data support this hypothesis, and the delay mechanism was found to rely on the expression of a soluble viral decoy receptor for Tnfα. This study is the first to report the control of behavioral fever by a pathogen.
SCHEDULE
11:00 - 12:00 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2019, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2019.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.