Lecture Series Cancer Research - "IMPACT OF OXIDATION RESISTANCE GENE 1 (OXR1) ON NEURONAL DEVELOPMENT AND METABOLISM"- Prof Magnar Bjoras
25/06/2019 11:00 to 25/06/2019 13:00 (Europe/Luxembourg)
Luxembourg,
Luxembourg
Speaker
Prof Magnar Bjoras is Professor, Clinic of Laboratory Medicine, University of Oslo and Oslo University Hospital and Univ of Oslo Professor, Dept of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim Head of Unit of Laboratory Medicine, NTNU, Trondheim.
Abstract
Emerging evidence strongly suggest that the TLDc family of proteins, includ-ing OXR1, are very important enzymes/proteins involved in neuronal develop-ment. Several neurodegenerative dis-eases are linked to SNPs in OXR1 and other proteins of the TLDc family, including Parkinson disease, Alzheimer disease and Amyotrophic lateral sclero-sis. The main hypothesis is that TLDc containing proteins such as OXR1 plays an important role in balancing ROS to avoid oxidative stress and development of neurological disorders and metabolic syndromes. We are using OXR1 deficient patient cells and Oxr1A deficient mice as models to investigate the impact of TLDc containing proteins on human disease, in particular neurological disorders and metabolic syndroms. We have data demonstrating that patients with mutations in the TLDc domain of OXR1 develop severe neurodegenerative disorders. Mice with brain specific iso-form A knockout (Oxr1A-/-) develop fatty liver associated with reduced growth hormone (GH) levels and indications of decreased GH receptor signaling in the liver. Our results further suggest that OXR1A acts as a coactivator of protein arginine methyltransferase 5 (PRMT5) increasing symmetrical dimethylation of histone H3 arginine 2 at Gh promoter in the pituitary gland and, consequently, regulate Gh transcription. We propose a novel role of OXR1A in oxidative stress signaling as a regulator of protein argi-nine methylation.
About the Lecture & Workshop series - cancer research
The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research during 2019-2020. Please find here the current programme for 2019.
These lectures will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.