Lecture Series Cancer Research - "HARNESSING IMMUNOGENIC CELL DEATH FOR IMMUNOTHERAPY AGAINST CANCER; FROM TRANSLATIONAL MEDICINE TO MOLECULAR MEDIATORS" - Prof Patrizia Agostinis
26/04/2018 12:00 to 26/04/2018 14:30 (Europe/Luxembourg)
Esch-sur-Alzette,
Luxembourg
Speaker
Prof Patrizia AGOSTINIS is Head of the Cell Death Research & Therapy
laboratory, Department of Cellular and Molecular Medicine, University of Leuven, KU, Leuven, Belgium.
Abstract
In recent times, crucial cellular processes supporting cancer cell growth and regulating the crosstalk between cancer cells with stromal cells, the major hallmarks of cancer, have been delineated, which are expected to facilitate anticancer therapy development. Therapeutic induction of endoplasmic reticulum (ER) stress is emerging as a strategy to target multiple hallmarks of cancer, and several ER stress-inducing therapies exhibit a positive clinical profile in cancer patients. Recently, therapy-induced ER stress has been shown to be a quintessential cancer cell-autonomous feature to elicit immunogenic cancer cell death (ICD). In therapeutic terms, ICD is the most favorable type of cell death since it combines efficient cancer cell killing (a cell autonomous feature) with the ability to activate the immune system against cancer (cell non-autonomous features), therefore resetting two key hallmarks of cancer; resistance to cell death and evasion from anti-tumour immunity. Here, I will discuss novel therapeutic applications of ICD for immunotherapy of glioblastoma and delineate novel molecular mechanisms underlying the ICD core machinery.
schedule
12.00 - 13.00: LECTURE
University of Luxembourg,
Maison du Savoir - Room 3.040.
13.00 - 14.30: 'meet & eat'
University of Luxembourg.
Maison du Savoir - Room 3.190
Registration required for the 'Meet & Eat' - send us an email
programme 2017-2018
About the Lecture & Workshop series - cancer research
The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research. Please find here he full programme for 2017-2018.
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.