Lecture Series Cancer Research - "CELLULAR AND MOLECULAR CIRCUITS THAT DETERMINE CD8+ T CELL PHENOTYPES IN CANCER"- Prof Ana C. Anderson
15/10/2019 11:00 to 15/10/2019 13:00 (Europe/Luxembourg)
Luxembourg,
Luxembourg
Speaker
Prof Ana C. Anderson is Associate Professor of Neurology, Harvard Medical School, Scientist, Brigham and Women’s Hospital, USA.
Abstract
The CD8+ T cell response is a critical com-ponent of anti-tumor immunity. Within tumor tissue, the CD8+ T cell response is heterogeneous with effector CD8+ T cells and dysfunctional or “exhausted” CD8+ T cells at opposite ends of the functional spectrum. We have applied an integrated and iterative approach involving experimental immunology, supervised and unsupervised genomics, and computational analyses to study CD8+ tumor-infiltrating lymphocytes (TILs). Through these efforts, we have uncovered a role for intracellular zinc in driving T cell dysfunction, leading to the discovery of distinct gene modules asso-ciated with the activated vs dysfunction-al T cell state in CD8+ TILs. We have also identified a transcriptional circuit down-stream of the immunoregulatory cytokine IL-27 that controls the expres-sion of an immunoregulatory module of co-inhibitory and co-stimulatory receptors in CD8+ TILs. Lastly, we have discovered a role for endogenous steroid hormone production and signaling within the tumor microenvironment in driving T cell dysfunction.
About the Lecture & Workshop series - cancer research
The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research during 2019-2020. Please find here the current programme for 2019.
These lectures will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.