Lecture Series Cancer Research - "A stitch in time saves nine - what about brain tumors?" - Prof Michel Mittelbronn
15/06/2017 11:00 to 15/06/2017 14:00 (Europe/Luxembourg)
Luxembourg,
Luxembourg
Speaker
Prof Michel MITTELBRONN is Head of the Department of Anatomic and
Molecular Pathology, Head of Luxembourg Centre of Neuropathology (LCNP) & (FNR) PEARL Chair, Dudelange, Luxembourg.
Abstract
Until recently, the search for underlying causes for the development of brain tumors was mainly focused on genetic alterations. However, it currently becomes more and more evident that many of the mutations that have been found in brain tumors are neither tumor-type specific, nor drugable but rather facilitate proliferative activity. With the pioneering methylation analysis of the O6-methylguanine-DNA-methylt rans ferase (MGMT) gene, a first association of epigenetic marks with outcome and prediction for sensitivity to alkylating agents in glioblastoma patients could be demonstrated. Most recently, an even stronger link between tumor morphology, protein expression profiles and patient prognosis with the epigenetic profile of brain tumors has been established. This epigenetic profiling currently challenges the gold-standard of histological typing and grading of brain tumors since epigenome-wide methylation profiling become a fast and very robust method in neuropathological diagnostics. The epigenetic signatures of brain tumors may provide further insights into the understanding why dinstinct brain tumors display a characteristic morphology and growth behaviour.
schedule
11.00 - 12.00: LECTURE
CHL, Amphitheatre
12.30 - 14.00: 'meet & eat'
LIH, BAM, Mc Clintock room
Registration required for the 'Meet & Eat' - send us an email
programme 2017-2018
About the Lecture & Workshop series - cancer research
The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research. Please find here the full programme for 2017-2018.
This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.