Lecture - Novel Trigger and function of Type 2 immunity: Damage-associated host DNA and host defense against venoms - Dr Thomas Marichal - 21 April 2016

21/04/2016 13:00 to 21/04/2016 16:30 (Europe/Luxembourg)

Esch/Alzette, Luxembourg


Dr Thomas Marichal, PhD is Junior Principal Investigator - “Chargé de recherches” of the F.R.S.-FNRS (National Fund for Scientific Research),
University of Liège, Belgium


Allergic disorders, helminth infections and aluminium-adjuvanted vaccination have in common the so-called “type 2” immune response that is induced and that can exert either pathological or protective functions. The research I am undertaking aims to understand how type 2 immune responses are induced, and what physiological functions they may have. The first part of the talk will be dedicated to recent findings indicating that host DNA released from damaged cells can act as a potent inducer of type 2 immunity in aluminium-adjuvanted vaccination (Marichal et al, Nature Medicine, 2011), but also in virus-induced asthma (unpublished data). During the second part of the talk I will present you experimental evidence demonstrating that immunoglobulin E (IgE) antibodies, which are mainly known in the context of deleterious allergic reactions, also enhance host protection against venoms (Marichal, Starkl et al., Immunity, 2013 & The Journal of Allergy and Clinical Immunology, 2016). This novel, beneficial function of IgE supports the “toxin hypothesis”, suggesting that allergic reactions act as immunological defenses against noxious substances (Profet, The Quarterly Review of Biology, 1991), and provides evidence for what may be the primary evolutionary benefit of IgE responses.

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13:00 - 14:30 : Lecture

Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle

15:00 - 16:30 : Workshop

House of BioHealth
Room Françoise Barré-Sinoussi

Registration required for the workshop - send us an email.

About the Lecture & Workshop series - Infection & Immunity

The LIH lecture and workshops series in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2016, followed by workshops especially dedicated to early-stage researchers.

Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.


32 rue Henri Koch
    Esch/Alzette 4354


From 21/04/2016 13:00
To 21/04/2016 16:30


Luxembourg Institute of Health
+352 26 970
+352 26 970 719