miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine?

December 01, 2014 By:
  • Goretti E
  • Wagner DR
  • Devaux Y.

miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.

2014 Dec. Trends Mol Med.20(12):716-25. Epub 2014 Nov 5.
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