Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease.

  • Competence Center for Methodology and Statistics
September 01, 2013 By:
  • Diederich NJ
  • Rufra O
  • Pieri V
  • Hipp G
  • Vaillant M.

BACKGROUND: Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson's disease (IPD). METHODS: Thirty-three patients who had IPD with a disease duration </= 3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication. RESULTS: Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire. CONCLUSIONS: The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage.

2013 Sep. Mov Disord.28(10):1443-6. Epub 2013 Jun 6.
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