CON-VINCE Study - Behind the scenes (PART I)

CON-VINCE as a role model for translational research collaboration in Luxembourg (PART I): IBBL a as key integrator

26 May 2020

5min read

CON-VINCE as a role model for translational research collaboration in Luxembourg (PART I)

IBBL a as key integrator

On 8th April, the CON-VINCE study was officially launched, with the aim to assess the spread dynamics of the COVID-19 disease among the Luxembourgish population.

Only 2 days later, all necessary material for starting up was already available (many thanks to LIH Buildings & Equipments team), coordination between the numerous partners around a single workflow was optimal, and all security conditions (many thanks to LIH Compliance Office team) were met to start the study. A real feat!

Within just 10 days, 1862 people were recruited, biosampled and tested!

Throwback to a logistical, technical and human challenge, which was met thanks to the incredible collaboration of all the IBBL, LIH, LCSB, CHL staff and partner laboratories from BioNext, Ketterthill and Laboratoires Réunis.

Odoo CMS - a big picture

(from left to right) Top Pic: Claire, Ana Lopes, Laura George, Margaux Henry, Maeva Munsch, Florian Simon, bottom left: Maeva M. Manuel C. François Massart (LCSB), Olivia Domingues, bottom right: Florian Simon, Charlene Verschueren, Ana Lopes, Margaux Schmitt, Bruno Santos 

Such an ant work was carried out by the IBBL Biorepository team and various volunteers. IBBL acted as a leader in the biosampling task force together with other stakeholders. Recruitment, as well as the coordination of collection partners, was a key point.
A huge thanks to IBBL Biorepository and Biorefinery teams who gave their all without counting the hours, so that everything could work smoothly!

As a result, in only 10 days, 3,370 kits for the collection of blood and pharyngeal samples and 1,650 kits for the collection of stool samples were distributed to the country's partner laboratories at an unprecedented cadence.

                                  Odoo CMS - a big picture
                                  Top left Pic: Maeva Munsch, Florian Simon, Top right: Simon bottom left: Laure Pauly, Valérie Schröder, bottom right: Katy Beaumont, Maeva M. et Florian S.

                                  Blood and naso-pharyngeal samples from study participants collected at the 3 partner laboratories  (Ketterthill, BioneXt and Laboratoires Réunis) and including home visits, were and transported (twice a day, sometimes more) to IBBL Biorepository by Biologistics (important role in the quick start of this study).

                                  They were then dispatched as follows:

                                  • naso-pharyngeal swabs to the LNS for SARS-CoV2 virus detection by amplifying ribonucleic acid (RNA) before returning to IBBL to be stored
                                  • blood samples to Biorefinery team for "processing"
                                  • transfer of forms for data encoding (cf step 5 photo bottom left)
                                    Odoo CMS - a big picture
                                    Top left: Olivia Domingues., Mareike Neumann, Monica Marchese, Top right: Camille Bellora, Kate Sokolowska bottom left: Olivia Domingues, Charlene Verschueren, Achilleas Pexeras, Margaux Schmitt, Lucie Remark, Francois Massart bottom right Borja GOMEZ RAMOS, Olivia Domingues ,Margaux Schmitt

                                        The “Processing” (manual and automated) consists in preparing different biological fractions for storage (serum or plasma for example). Training in the management of serum and plasma, naso-pharyngeal swabs, extracted RNA and stool aliquoting was necessary for volunteers and was organized in record time. The treated samples could then be redistributed to the LNS and LIH for analysis.

                                        Daily processing of samples from 39 to 349 patients per day which, at the end of the first wave, allowed the storage of more than 37,000 aliquots, a large part of which was already used for research purposes within CON-VINCE and beyond.


                                        Odoo CMS - a big picture
                                        Top left: Linda Hansen; bottom left pic: Maxime Hansen, Laure Pauly, Valerie Schröder; right: Femke Wauters. All from the Parkinson Research Clinic of NCER-PD.

                                          A proper data collection was key to carry out this study.

                                          Proper data encoding of the paper forms received with the samples was key to carry out this study and was done by our clinical team partners at CHL and UL. To link the participants to their samples through the paper forms and their questionnaire answers, the data team of the LCSB Computing Platform worked day and night from the beginning of the study to set up the complex and secure data infrastructure. This allows the information to be properly stored and synchronized, and updated daily with the results of the tests for the virus.

                                          All those activities are still ongoing with the same team spirit! Thumbs up to all teams working on this great project!

                                          This unprecedented study, due to its complexity and urgency, was like the outline of a music score, which each one of us fed with his musical orientations. Conductors agreed, musicians practiced, others discovered their instruments, adapted, trained and above all helped each other, all in record time. The ultimate goal is to play this collaborative score in unison. Objective achieved: The melody is there! »

                                          Katy Beaumont, Head of BioRepository at IBBL and COVID Fighter.